Born in Milan in 1963, Francesca Simen graduated in Architecture at the Polytechnic University of Milan in 1989 and is member of the Order of Architects of Milan where she lives and works. From 1990 to 2003 she collaborated with the architect Antonio Citterio dealing with interior architecture in the residential and commercial sectors.

In 2003 she started to work with Stefano Gallizioli and they founded ANG42, a multidisciplinary design studio, which deals with interior architecture, design, set-ups. Together they work in Italy and abroad, taking care of the phases from project to implementation, often also dealing with the design of the furnishings, thus combining their personal experiences in the furniture and design sector.

In addition to the numerous private residences, which constitute their main activity, they work also in the office and hospitality fields. In 2006 they established a branch in Dublin, which joins the activity of the Milanese studio.